Maybe Anne was mad at Sasha for mistakenly betraying her again, is because she always let her selfish ambition and negative emotions get the best of her every time someone did terrible things to her; just like how she gets mad at Hop Pop for mistakenly burying the Calamity Box for thinking its too dangerous just to keep Anne in Amphibia forever. And that's one of the reason why she gets like that to Sasha. It's because she didn't love herself.